Takinib - CAS# 1111556-37-6 60071 is a potent inhibitor of

is a potent inhibitor of ferroptosis with an EC50 ~60 nM

InChi: InChI=1S/C24H27N5O2/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29/h3-9

and stromal protection

Nature Biotechnology 27

SKI-II reverses the chemoresistance of SGC7901/DDP gastric cancer cells

Takinib - CAS# 1111556-37-6 60071 is a potent inhibitor ofTakinib, CAS No. 1111556 37 6, is a selective TAK1 inhibitor that induces apoptosis following TNF stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is an inhibitor of autophosphorylated and non phosphorylated TAK1 that binds within the ATP binding pocket and inhibits by slowing down the rate limiting step of TAK1 activation. Product information CAS Number: 1111556 37 6 Molecular Weight: 322. 36 Formula: