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KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60077 7 µM concentration in beta

KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60077 7 µM concentration in beta

Name: KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60077 7 µM concentration in beta
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SKU: 56506749382
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SKU: 56506749382

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KYA1797K - Wnt/β-catenin Inhibitor. CAS# 1956356-56-1 60077 7 µM concentration in betaKYA1797K, CAS No. 1956356 56 1, is a highly potent and selective Wnt catenin inhibitor with IC50 ~0. 75 M (TOPflash assay). It binds directly to the regulators of G protein signaling domain of axin, initiating catenin and Ras degradation through enhancement of the catenin destruction complex activating GSK3. KYA1797K can effectively suppress the growth of CRCs harboring APC and KRAS mutations, as shown by various in vitro studies and by in vivo

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Description

7 µM concentration in beta cell proliferation assays

and has > 50-fold selectivity against other protein kinases

2-b]pyridin]-3-ol

4 μM) with respect to Shh and as a noncompetitive inhibitor (Ki = 6

3 μM for KDM4B

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