AZD2014 - mTOR Inhibitor. CAS# 1009298-59-2 0147 Chemical Name: (E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide

Chemical Name: (E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamide

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G-749 appears to be a promising next-generation drug candidate for the treatment of relapsed and refractory AML patients with various FLT3-ITD/FLT3-TKD mutants and further shows the ability to overcome drug resistance (Blood

and it could effectively block both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression

AZD2014 - mTOR Inhibitor. CAS# 1009298-59-2 0147 Chemical Name: (E)-1-methyl-N-(2-methyl-4-(o-tolyldiazenyl)phenyl)-1H-pyrazole-5-carboxamideAZD2014, CAS No. 1009298 59 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 2. 8 nM). It displays a high level of selectivity against other members of the PIKK family (IC50 against PI3K isoforms , , , = 3. 8 M, >30 M, >30 M and >29 M, respectively) and is inactive against a general panel of over 200 kinases when tested at 10 M. AZD2014 inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235 236 ) IC50 = 0. 2 M, pAKT (S473) IC50