Tamibarotene - CAS# 94497-51-5 oxifen citrate JW74 induces reduced cell growth

JW74 induces reduced cell growth in all three tested cell lines

InChiKey: ACGUYXCXAPNIKK-UHFFFAOYSA-N

thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability

[Epub ahead of print] PubMed PMID: 27364361

Leuprolide acetate is the acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone

Tamibarotene - CAS# 94497-51-5 oxifen citrate JW74 induces reduced cell growthTamibarotene, also known as SY 1425, is an orally active, synthetic retinoid, developed to overcome all trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL 60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular