TPCA-1 - CAS# 507475-17-4 olet Ginsenoside Rb3 is found in

Ginsenoside Rb3 is found in species of Panax

7(4):609-26

InChi: InChI=1S/C21H24N2O2/c1-13(2)22-9-10-23-20-7-5-16(14(3)24)11-18(20)19-12-17(15(4)25)6-8-21(19)23/h5-8

309(3):E302-10

Influenza B and A/H1N1 viruses were sensitive to oseltamivir (mean B IC50 value: 13 nM

TPCA-1 - CAS# 507475-17-4 olet Ginsenoside Rb3 is found inTPCA 1 is a potent IKK 2 inhibitor. TPCA 1 is also an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation in vivo. It selectively repressed proliferation of NSCLC cells with constitutive STAT3 activation. TPCA 1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF B and STAT3 pathways for lung cancers harboring mutant EGFR. Therefore, synergistic